Sérový amyloid A jako efektivní marker stupne operacní záteze a rizika komplikací
[Serum amyloid A as an effective marker for the assessment of surgical trauma and risk of post-operative complications]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články, práce podpořená grantem
PubMed
16671208
- MeSH
- biologické markery krev MeSH
- C-reaktivní protein analýza MeSH
- dospělí MeSH
- fyziologický stres krev diagnóza etiologie MeSH
- gynekologické chirurgické výkony škodlivé účinky MeSH
- interleukin-6 krev MeSH
- leiomyom chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory dělohy chirurgie MeSH
- počet leukocytů MeSH
- pooperační komplikace krev diagnóza MeSH
- pooperační období MeSH
- reakce akutní fáze krev diagnóza etiologie MeSH
- sérový amyloid A analýza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
- interleukin-6 MeSH
- sérový amyloid A MeSH
OBJECTIVE: To analyze relations among acute phase reactants in a group of 40 women operated for uterine myom by laparoscopy and open surgery. DESIGN: Prospective study. METHODS: Plasma concentrations of C-reactive protein (CRP), serum amyloid A (SAA) and interleukin 6 (IL-6) were measured together with leukocytes in blood before operation, 24 and 72 hours post operation, respectively. RESULTS: Leukocytes and IL-6 displayed minimal response and decreased quickly after operation to preoperative levels. Concentrations of CRP and SAA remained increased after operation. There were no relationships between leukocytes and acute phase reactants. Normal leukocytes 72 hours post operation were found in 1/3 of women with increased at least one acute phase reactants and in 1/4 of women with increased at least two markers. Typ of surgery, surgical stress and length of surgery were related to the concentration of CRP, IL-6 and SAA. CONCLUSION: Changes in SAA 24 hours after operation are similar to CRP and IL-6. Surgical stress, length of operation and possible risk 72 hours after operation are best predicted by CRP and SAA (at that time IL-6 and leukocytes are practically normal). Maximal increase was found for SAA concentrations. Thus SAA seems to be suitable marker of early postoperative complications.