Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cell Nucleus metabolism MeSH
- Cell Line MeSH
- Gene Expression MeSH
- Phylogeny MeSH
- Transcription, Genetic MeSH
- Conserved Sequence MeSH
- Humans MeSH
- Myosin Type I chemistry genetics isolation & purification metabolism MeSH
- Mice MeSH
- Vertebrates genetics metabolism MeSH
- Amino Acid Sequence MeSH
- Sequence Homology, Nucleic Acid MeSH
- Serum chemistry MeSH
- Nucleic Acid Amplification Techniques MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Myosin Type I MeSH
Nuclear myosin I (NMI) is a single-headed member of myosin superfamily localized in the cell nucleus which participates along with nuclear actin in transcription and chromatin remodeling. We demonstrate that NMI is present in cell nuclei of all mouse tissues examined except for cells in terminal stages of spermiogenesis. Quantitative PCR and western blots demonstrate that the expression of NMI in tissues varies with the highest levels in the lungs. The expression of NMI is lower in serum-starved cells and it increases after serum stimulation. The lifespan of NMI is longer than 16 h as determined by cycloheximide translation block. A homologous protein is expressed in human, chicken, Xenopus, and zebrafish as shown by RACE analysis. The analysis of genomic sequences indicates that almost identical homologous NMI genes are expressed in mammals, and similar NMI genes in vertebrates.
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