Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16962332
DOI
10.1016/j.bmc.2006.08.013
PII: S0968-0896(06)00674-2
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Skin metabolism MeSH
- Fatty Alcohols chemistry pharmacokinetics MeSH
- Fatty Acids chemistry pharmacokinetics MeSH
- Permeability MeSH
- Swine MeSH
- Theophylline pharmacokinetics MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Fatty Alcohols MeSH
- Fatty Acids MeSH
- Theophylline MeSH
In order to investigate the effect of terminal chain branching in the skin permeation enhancers, seven alcohols and seven acids with the chain length of 8-12 carbons and terminal methyl or ethyl branching were prepared. Their transdermal permeation-enhancing activities were evaluated in vitro using theophylline as a model permeant and porcine skin, and compared to those of the linear standards. Terminal methyl branching increased the enhancing activity only in 12C acid, no effect was seen in the shorter ones. Terminal ethyl however produced a significant increase in activity. In the alcohols, the branching was likely to change the mode of action, due to a different relationship between the activity and the chain length.
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