Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study
Jazyk angličtina Země Itálie Médium print-electronic
Typ dokumentu časopisecké články, pozorovací studie
Grantová podpora
64165
RVO VFN
PubMed
39455532
PubMed Central
PMC11614926
DOI
10.1007/s13760-024-02676-w
PII: 10.1007/s13760-024-02676-w
Knihovny.cz E-zdroje
- Klíčová slova
- Brain atrophy, Cholesterol, HDL, LDL, Lesion volume, Lipid, MRI, Multiple sclerosis,
- MeSH
- cholesterol krev MeSH
- dospělí MeSH
- HDL-cholesterol * krev MeSH
- kohortové studie MeSH
- LDL-cholesterol krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- magnetická rezonanční tomografie * MeSH
- mozek * diagnostické zobrazování patologie MeSH
- průřezové studie MeSH
- roztroušená skleróza * diagnostické zobrazování krev patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- Názvy látek
- cholesterol MeSH
- HDL-cholesterol * MeSH
- LDL-cholesterol MeSH
OBJECTIVES: This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. MATERIALS AND METHODS: We included 1.505 patients with 4.966 time points including complete lipid, clinical, and imaging data. The time among lipid, brain MRI and clinical measures was under 90 days. Cross-sectional statistical analysis at baseline was performed using an adjusted linear regression and analysis of longitudinal lipid and MRI measures data was performed using adjusted linear mixed models. RESULTS: We found associations between higher high-density lipoprotein cholesterol (HDL-C) and lower brain parenchymal fraction (BPF) at cross-sectional analysis at baseline (B = -0.43, CI 95%: -0.73, -0.12, p = 0.005), as well as in longitudinal analysis over follow-up (B = -0.32 ± 0.072, χ2 = 36.6; p = < 0.001). Higher HDL-C was also associated with higher T2-lesion volume in longitudinal analysis (B = 0.11 ± 0.023; χ2 = 23.04; p = < 0.001). We observed a weak negative association between low-density lipoprotein cholesterol (LDL-C) levels and BPF at baseline (B = -0.26, CI 95%: -0.4, -0.11, p = < 0.001) as well as in longitudinal analysis (B = -0.06 ± 0.03, χ2 = 4.46; p = 0.03). T2-LV did not show an association with LDL-C. We did not find any association between lipid measures and disability. The effect of lipid levels on MRI measures and disability was minimal (Cohen f2 < 0.02). CONCLUSIONS: Our results contradict the previously described exclusively positive effect of HDL-C on brain atrophy in patients with MS. Higher LDL-C was weakly associated with higher brain atrophy but not with higher lesion burden.
Zobrazit více v PubMed
1. Alfredsson, L. and T. Olsson, PubMed PMC
2. Orth, M. and S. Bellosta, PubMed PMC
3. Erum, U., T. Ahsan, and D. Khowaja, PubMed PMC
4. Tselios, K., C. Koumaras, D.D. Gladman, and M.B. Urowitz, PubMed
5. Palladino, R., R.A. Marrie, A. Majeed, and J. Chataway, PubMed PMC
6. Lorincz, B., et al., PubMed
7. Zhornitsky, S., et al., PubMed
8. Murali, N., et al., PubMed
9. Uher, T., et al., PubMed PMC
10. Weinstock-Guttman, B., et al., PubMed
11. McComb, M., et al., PubMed
12. Thompson, A.J., et al., PubMed
13. Uher, T., et al., PubMed
14. Langsted, A. and B.G. Nordestgaard, PubMed
15. Selya, A.S., et al., PubMed PMC
16. Barter, P.J., et al., PubMed
17. Weinstock-Guttman, B., et al., PubMed PMC
18. Fellows, K., et al., PubMed PMC
19. McComb, M., et al., PubMed
20. Feingold, K.R. and C. Grunfeld, PubMed
21. De Oliveira, E.S.E.R., et al., PubMed
22. Blumenfeld Kan, S., E. Staun-Ram, D. Golan, and A. Miller, PubMed PMC
23. Milstein, J.L., et al., PubMed PMC
24. Palavra, F., et al., PubMed PMC
25. Charles-Schoeman, C., et al., PubMed PMC
26. McMahon, M., et al., PubMed PMC
27. Jorissen, W., et al., PubMed PMC
28. G, H.B., V.S. Rao, and V.V. Kakkar, PubMed PMC
29. Kontush, A. and M.J. Chapman, PubMed
30. Ferretti, G. and T. Bacchetti, PubMed
31. Wang, P., K. Xie, C. Wang, and J. Bi, PubMed
32. Houdebine, L., et al., PubMed
33. Radikova, Z., et al., PubMed PMC
34. McNeil, J.J., et al., PubMed PMC
35. Sultana Monira Hussain, C.R., Andrew M. Tonkin, Paul Lacaze, Trevor T.-J. Chong, Lawrence J. Beilin, Chenglong Yu, Gerald F. Watts, Joanne Ryan, Michael E. Ernst, Zhen Zhou and J.J.M. Johannes T. Neumann, PubMed PMC
36. von Eckardstein, A., B.G. Nordestgaard, A.T. Remaley, and A.L. Catapano, PubMed PMC
