The role of cholesterol metabolism in multiple sclerosis: From molecular pathophysiology to radiological and clinical disease activity
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
35398271
DOI
10.1016/j.autrev.2022.103088
PII: S1568-9972(22)00058-1
Knihovny.cz E-zdroje
- Klíčová slova
- HDL, LDL, LXR, MRI, multiple sclerosis, Oxysterols,
- MeSH
- cholesterol metabolismus MeSH
- lidé MeSH
- lipoproteiny HDL metabolismus MeSH
- lipoproteiny LDL metabolismus MeSH
- metabolismus lipidů MeSH
- roztroušená skleróza * diagnostické zobrazování metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- cholesterol MeSH
- lipoproteiny HDL MeSH
- lipoproteiny LDL MeSH
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS leading to demyelination and axonal degeneration. An increasing body of evidence suggests that lipid metabolism is associated with adverse clinical and MRI outcomes in MS. In this review we summarize the findings of association between low-density lipoproteins (LDL), high-density lipoproteins (HDL), their apolipoproteins and oxysterols with clinical and radiological disease activity in MS. Although the causality between disease activity in MS and abnormalities in lipid metabolism has not yet been elucidated, we suggest that advances in this field of research have the potential to improve understanding of MS pathophysiology and the identification of new treatment targets and strategies.
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