Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu klinické zkoušky, časopisecké články, práce podpořená grantem
PubMed
16968804
DOI
10.1210/jc.2006-0382
PII: jc.2006-0382
Knihovny.cz E-zdroje
- MeSH
- adiponektin krev metabolismus MeSH
- cvičení fyziologie MeSH
- cytokiny krev metabolismus MeSH
- exprese genu MeSH
- interleukin-1beta krev metabolismus MeSH
- interleukin-6 krev metabolismus MeSH
- inzulinová rezistence fyziologie MeSH
- leptin krev metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita krev metabolismus MeSH
- podkožní tuk metabolismus MeSH
- svalová síla fyziologie MeSH
- TNF-alfa krev metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adiponektin MeSH
- ADIPOQ protein, human MeSH Prohlížeč
- cytokiny MeSH
- interleukin-1beta MeSH
- interleukin-6 MeSH
- leptin MeSH
- TNF-alfa MeSH
CONTEXT: Obesity is characterized by a low-grade inflammatory state, which could play a role in insulin resistance. Dynamic strength training improves insulin sensitivity. OBJECTIVE: The objective of this study was to investigate, in obese subjects, whether the insulin sensitizing effect of dynamic strength training is associated with changes in plasma levels and gene expression of adipokines potentially involved in the development of insulin resistance. DESIGN: Twelve obese male subjects were investigated before and at the end of 3 months of dynamic strength training. Insulin sensitivity was evaluated using euglycemic-hyperinsulinemic clamp. Blood samples and needle biopsy samples of sc abdominal adipose tissue were obtained. The plasma levels and adipose tissue mRNA levels of adiponectin, leptin, IL-1beta, IL-6, and TNF-alpha were determined. RESULTS: The training induced an increase in the whole-body glucose disposal rate by 24% (P = 0.04). The body weight was not altered during the training. Plasma levels of leptin decreased during the training (16.6 +/- 6.3 vs. 13.1 +/- 5.7 ng/ml) by 21% (P < 0.02), whereas no change in plasma levels of other adipokines and C-reactive protein was observed. Gene expression of the investigated adipokines was not changed in sc adipose tissue during the training. CONCLUSIONS: In obese subjects, the dynamic strength training resulted in an improvement of whole-body insulin sensitivity. The increase in insulin sensitivity was not associated with training-induced modifications of plasma levels or adipose tissue gene expression of adipokines supposedly involved in the development of insulin resistance.
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