Changes of cholinesterase activities in the plasma and some tissues following administration of L-carnitine and galanthamine to rats
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17125927
DOI
10.1016/j.neulet.2006.09.087
PII: S0304-3940(06)00990-6
Knihovny.cz E-resources
- MeSH
- Enzyme Activation drug effects MeSH
- Butyrylcholinesterase blood MeSH
- Cholinesterase Inhibitors administration & dosage MeSH
- Cholinesterases metabolism MeSH
- Galantamine administration & dosage MeSH
- Carnitine administration & dosage MeSH
- Rats MeSH
- Drug Interactions MeSH
- Linear Models MeSH
- Brain drug effects MeSH
- Rats, Wistar MeSH
- Vitamin B Complex administration & dosage MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Butyrylcholinesterase MeSH
- Cholinesterase Inhibitors MeSH
- Cholinesterases MeSH
- Galantamine MeSH
- Carnitine MeSH
- Vitamin B Complex MeSH
Changes of acetylcholinesterase (AChE) activities in the hypophysis and brain (frontal cortex, hippocampus, medial septum and basal ganglia), and butyrylcholinesterase in plasma and liver following galanthamine (GAL) administration were studied in rats pretreated with L-carnitine (CAR). Following only GAL administration (10 mg/kg, i.m.), both cholinesterases (without clinical symptoms of GAL overdosage) were significantly inhibited. Pretreatment with CAR (3 consecutive days, 250 mg/kg, p.o.) followed by GAL administration showed higher AChE inhibition in comparison with single GAL administration. However, a statistically significant difference was observed for AChE in the hippocampus only. The activity of peripheral cholinesterases was not influenced by CAR pretreatment. Thus, pretreatment with CAR enhanced AChE inhibition in some brain parts of the rat following GAL administration.
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