The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články, randomizované kontrolované studie, práce podpořená grantem
PubMed
17277734
PII: NEL280107A01
Knihovny.cz E-zdroje
- MeSH
- antidepresiva terapeutické užití MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- kombinovaná terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- panická porucha patofyziologie terapie MeSH
- prefrontální mozková kůra patofyziologie MeSH
- selektivní inhibitory zpětného vychytávání serotoninu terapeutické užití MeSH
- stupeň závažnosti nemoci MeSH
- transkraniální magnetická stimulace metody MeSH
- úzkost patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- antidepresiva MeSH
- selektivní inhibitory zpětného vychytávání serotoninu MeSH
BACKGROUND: Transcranial magnetic stimulation (rTMS) can modulate cortical activity. The goal of our study was to assess whether rTMS would facilitate effect of serotonin reuptake inhibitors in patients with panic disorder. METHOD: Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We use 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study,. Psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer. RESULTS: Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments. CONCLUSION: Low frequency rTMS administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham rTMS add on serotonin reuptake inhibitors in patients with panic disorder.
Towards causal mechanisms of consciousness through focused transcranial brain stimulation