Advanced glycation end-product pentosidine is not a relevant marker of disease activity in patients with rheumatoid arthritis
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
17298211
DOI
10.33549/physiolres.931147
PII: 1147
Knihovny.cz E-zdroje
- MeSH
- arginin analogy a deriváty krev MeSH
- biologické markery krev MeSH
- chrupavkový oligomerní matrixový protein MeSH
- ELISA MeSH
- extracelulární matrix - proteiny metabolismus MeSH
- glykoproteiny metabolismus MeSH
- kloubní chrupavka patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lysin analogy a deriváty krev MeSH
- matriliny MeSH
- produkty pokročilé glykace krev MeSH
- revmatoidní artritida krev imunologie patologie MeSH
- synoviální tekutina metabolismus MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- zánět metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- arginin MeSH
- biologické markery MeSH
- chrupavkový oligomerní matrixový protein MeSH
- extracelulární matrix - proteiny MeSH
- glykoproteiny MeSH
- lysin MeSH
- matriliny MeSH
- pentosidine MeSH Prohlížeč
- produkty pokročilé glykace MeSH
- TSP5 protein, human MeSH Prohlížeč
Advanced glycation end-product (AGE) pentosidine has previously been demonstrated in different tissues and body fluids. It was suggested as a novel marker for evaluating the pathologic activity in rheumatoid arthritis (RA). In this study we analyzed the relation between pentosidine and markers of inflammation, cartilage turnover, immune response, and disease status of RA. Using HPLC, we analyzed pentosidine in serum and synovial fluid from 39 patients with RA and in serum from 38 healthy controls. Cartilage oligomeric matrix protein (COMP) and antibodies to CCP (anti-CCP) were measured by ELISA. Clinical disease status was assessed by Disease Activity Score 28 (DAS 28) and functional status by Health Assessment Questionnaire (HAQ). We demonstrated significantly higher serum levels of pentosidine in RA patients in comparison with controls. Pentosidine in serum significantly correlated with pentosidine in synovial fluid. Serum pentosidine levels were associated with erythrocyte sedimentation rate (p<0.03) but not with CRP, COMP, anti-CCP antibodies, DAS 28, or HAQ. In contrast to previous studies, we could not show any correlation of pentosidine levels with inflammatory status, clinical disease activity, markers of immune response, or cartilage breakdown. However, AGEs can be suggested as important players participating in joint destruction rather than markers of disease activity.
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