Cardiac adaptation to chronic high-altitude hypoxia: beneficial and adverse effects
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
17442631
DOI
10.1016/j.resp.2007.03.005
PII: S1569-9048(07)00091-2
Knihovny.cz E-resources
- MeSH
- Acclimatization physiology MeSH
- Atmospheric Pressure MeSH
- Chronic Disease MeSH
- Hypoxia complications metabolism MeSH
- Ischemia etiology metabolism MeSH
- Oxygen blood MeSH
- Myocardium metabolism MeSH
- Altitude * MeSH
- Myocardial Reperfusion Injury etiology metabolism MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Oxygen MeSH
This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized.
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