Adipokinetic hormone-induced enhancement of antioxidant capacity of Pyrrhocoris apterus hemolymph in response to oxidative stress
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
17512258
DOI
10.1016/j.cbpc.2007.04.005
PII: S1532-0456(07)00109-3
Knihovny.cz E-zdroje
- MeSH
- antioxidancia metabolismus farmakologie MeSH
- glutathion metabolismus MeSH
- hemolymfa účinky léků metabolismus MeSH
- herbicidy farmakologie MeSH
- Heteroptera účinky léků metabolismus MeSH
- hmyzí hormony metabolismus farmakologie MeSH
- kombinovaná farmakoterapie MeSH
- kyselina pyrrolidonkarboxylová analogy a deriváty metabolismus farmakologie MeSH
- mozek účinky léků metabolismus MeSH
- oligopeptidy metabolismus farmakologie MeSH
- oxidační stres účinky léků fyziologie MeSH
- paraquat farmakologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adipokinetic hormone MeSH Prohlížeč
- antioxidancia MeSH
- glutathion MeSH
- herbicidy MeSH
- hmyzí hormony MeSH
- kyselina pyrrolidonkarboxylová MeSH
- oligopeptidy MeSH
- paraquat MeSH
The in vivo effects of oxidative stress on adipokinetic hormone (AKH) titer in short-winged (brachypterous) males of the firebug Pyrrhocoris apterus were tested using paraquat (PQ), a bipyridilium herbicide. PQ undergoes a cyclic redox reaction with oxygen during microsomal and electron transfer reactions forming free radicals in the insect body. Oxidative insult (40 pmol PQ) resulted in enhanced protein carbonylation (a biomarker for oxidative stress) and a depletion of glutathione (GSH) pool in the hemolymph. Interestingly, AKH titer was significantly enhanced in hemolymph at 4 h post inoculation of PQ, while its content in CNS (brain with corpora cardiaca) showed non-specific changes in comparable period. Co-injection of AKH with PQ (40 pmol each) reversed these effects by decreasing protein carbonyl formation, increasing reduced GSH levels, and enhancing the total antioxidant capacity of cell free plasma. Our results indicate that there is a positive feedback regulation between an oxidative stressor action and the level of AKH in insect body, and that AKHs might be involved in the activation of antioxidant protection mechanism.
Institute of Entomology Academy of Sciences Branisovská 31 CZ 370 05 Ceské Budejovice Czech Republic
Citace poskytuje Crossref.org
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