Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen
Language English Country Czech Republic Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17949247
DOI
10.33549/physiolres.931338
PII: 1338
Knihovny.cz E-resources
- MeSH
- GABA-B Receptor Agonists * MeSH
- Anticonvulsants pharmacology MeSH
- Baclofen pharmacology MeSH
- GABA Agonists pharmacology MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Organophosphorus Compounds pharmacology MeSH
- Pentylenetetrazole MeSH
- Rats, Wistar MeSH
- Reaction Time drug effects MeSH
- Receptors, GABA-B metabolism MeSH
- Age Factors MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced metabolism prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 3-aminopropyl(methyl)phosphinic acid MeSH Browser
- GABA-B Receptor Agonists * MeSH
- Anticonvulsants MeSH
- Baclofen MeSH
- GABA Agonists MeSH
- Organophosphorus Compounds MeSH
- Pentylenetetrazole MeSH
- Receptors, GABA-B MeSH
GABA-B receptor agonist SKF97541 exhibits age-dependent anticonvulsant and proconvulsant actions in developing rats. It suppressed tonic phase of generalized seizures induced by pentetrazol in 7-, 12- and 18-day-old rats and increased their latency in 7- and 12-day-old animals. Other results in 18-day-old animals are not so clear. SKF97541 blocked the appearance of minimal clonic seizures, but tended to decrease latencies of both types of seizures. In addition, it significantly decreases latency of generalized seizures in adult rats. The mixed effects of SKF97541 are in agreement with those of baclofen but there are substantial differences between the actions of these two agonists in individual age groups.
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