Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18037158
DOI
10.1016/j.ygyno.2007.10.016
PII: S0090-8258(07)00846-3
Knihovny.cz E-zdroje
- MeSH
- antigen Ki-67 biosyntéza MeSH
- antigeny CD3 imunologie MeSH
- antigeny nádorové biosyntéza MeSH
- DNA vazebné proteiny biosyntéza MeSH
- DNA-topoisomerasy typu II biosyntéza MeSH
- dospělí MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorový supresorový protein p53 biosyntéza MeSH
- nádory vaječníků imunologie metabolismus patologie MeSH
- prognóza MeSH
- protein X asociovaný s bcl-2 biosyntéza MeSH
- protoonkogenní proteiny c-bcl-2 biosyntéza MeSH
- receptor erbB-2 biosyntéza MeSH
- receptory progesteronu biosyntéza MeSH
- retrospektivní studie MeSH
- staging nádorů MeSH
- tumor infiltrující lymfocyty imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antigen Ki-67 MeSH
- antigeny CD3 MeSH
- antigeny nádorové MeSH
- BAX protein, human MeSH Prohlížeč
- DNA vazebné proteiny MeSH
- DNA-topoisomerasy typu II MeSH
- nádorový supresorový protein p53 MeSH
- protein X asociovaný s bcl-2 MeSH
- protoonkogenní proteiny c-bcl-2 MeSH
- receptor erbB-2 MeSH
- receptory progesteronu MeSH
- TP53 protein, human MeSH Prohlížeč
OBJECTIVE: Epithelial ovarian cancer (EOC) is the most common cause of death among gynecological malignancies in Europe and North America. Although the presence of tumor-infiltrating mononuclear cells has been documented in EOC, the association of tumor-infiltrating mononuclear cells with clinical outcome remains controversial. The aim of the present study was to investigate the prognostic significance of CD3+ tumor-infiltrating T lymphocytes (TIL) on overall survival of EOC patients. METHODS: We evaluated retrospectively by immunohistochemistry the distribution of CD3+ TIL in tumor specimens of 116 EOC patients. The expression of estrogen and progesterone receptors, Ki-67, DNA topoisomerase IIalpha, p21, p53, HER-2/neu, bax and bcl-2 was also evaluated by immunohistochemistry. The prognostic significance of CD3+ TIL and other immunohistochemical and clinical parameters was evaluated with log-rank test. Multivariate analysis was performed using the Cox regression. RESULTS: CD3+ TIL were observed in all tumor samples, both in cancer stroma and within cancer epithelium (intraepithelial TIL). The median counts of stromal TIL and intraepithelial TIL were 338 lymphocytes/mm2 (range 81-2094 lymphocytes/mm2) and 125 lymphocytes/mm2 (range 7-481 lymphocytes/mm2), respectively. In univariate analysis, age, stage, grade, presence of residual tumor, expression of progesterone receptors, Ki-67, DNA topoisomerase IIalpha and intraepithelial CD3+ TIL count were significant predictors of overall survival. On multivariate analysis, only the presence of residual tumor, stage, expression of progesterone receptors and intraepithelial CD3+ TIL count were found to be significant independent predictors of overall survival. CONCLUSION: Present data indicate that the intraepithelial CD3+ TIL count is a significant prognostic factor in EOC.
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