RNA silencing in mammalian oocytes and early embryos
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Embryo, Mammalian metabolism MeSH
- Mice MeSH
- Oocytes metabolism MeSH
- RNA Interference * MeSH
- Signal Transduction MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
RNA silencing is a common term for homology-dependent silencing phenomena found in the majority of eukaryotic species. RNA silencing pathways share several conserved components. The common denominator of these pathways is the presence of specific, short (21-25 nt) RNA molecules generated from different double-stranded RNA substrates by a specific RNase III activity. Short RNA molecules serve as a template for sequence-specific effects including transcriptional silencing, mRNA degradation, and inhibition of translation. This review will discuss possible roles of RNA silencing pathways in mouse oocytes and early embryos as well as the use of RNA silencing for experimental inhibition of gene expression in this model system.
References provided by Crossref.org
The oocyte-to-embryo transition in mouse: past, present, and future
Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes
P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes
