Successful use of olanzapine in adolescent monozygotic twins with catatonic schizophrenia resistant to electroconvulsive therapy: case report
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
PubMed
18283244
PII: NEL290108C02
Knihovny.cz E-zdroje
- MeSH
- antipsychotika terapeutické užití MeSH
- benzodiazepiny terapeutické užití MeSH
- dvojčata monozygotní psychologie MeSH
- elektrokonvulzívní terapie MeSH
- lidé MeSH
- mladiství MeSH
- olanzapin MeSH
- schizofrenie katatonická farmakoterapie genetika psychologie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antipsychotika MeSH
- benzodiazepiny MeSH
- olanzapin MeSH
We describe a case of monozygotic (MZ) male twins (14.6 years old) who suffered from a severe form of catatonic schizophrenia. On admission, the principal symptoms of the brothers were stupor, mutism, catatonic posturing, rigidity, negativism, and refusal of food and liquids. They were treated with electroconvulsive therapy (ECT) with no effect (twin A) and almost no effect (twin B). Both twins improved with initiation of olanzapine therapy. Twin B showed a marked improvement by week 2 on a dose of 10 mg daily (qd). Improvement in twin A was seen by week 4 on a dose of 15 mg qd. Twin B was discharged after 8 weeks and twin A after 11 weeks of olanzapine treatment. This appears to be the first report on concordant positive responses to olanzapine in MZ twins with catatonic schizophrenia, as well as, the first report on concordant resistance to ECT.
Atypical antipsychotics in the treatment of early-onset schizophrenia
