Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity
Jazyk angličtina Země Řecko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
18292938
Knihovny.cz E-zdroje
- MeSH
- buněčné linie MeSH
- buňky NK patologie MeSH
- cytotoxické testy imunologické MeSH
- gnotobiologické modely imunologie fyziologie MeSH
- inbrední kmeny potkanů MeSH
- karcinom imunologie mikrobiologie patologie MeSH
- kolorektální nádory imunologie mikrobiologie patologie MeSH
- krysa rodu Rattus MeSH
- lymfocyty patologie MeSH
- novorozená zvířata MeSH
- potkani Wistar MeSH
- přirozená imunita fyziologie MeSH
- progrese nemoci MeSH
- proliferace buněk MeSH
- střeva imunologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Intestinal microbiota are considered to play an important role both in colorectal tumor development and in the modulation of mucosal immunity. Studies on animals reared in germ-free (GF, without intestinal microbiota) versus conventional (CV, with regular microbiota colonization of the bowel) conditions can aid in clarifying the influence of bacteria on carcinogenesis and the anticancer immune response. The capability of the intestinal environment to modulate anticancer immunity not only at the mucosal but also at the systemic level is still an open question. In our study we found that, following the same protocol of colorectal cancer induction, GF rats developed less and smaller tumors than CV rats. The GF rats that did not develop cancer also presented a better anticancer immune response with an increase in NK, NKT, CTL, B cells and cytotoxicity in peripheral blood. We hypothesize that the lower antigenic challenge and the absence of the 'physiological inflammation', caused by the commensal microbiota in the gut of CV rats, may enhance the capability of the GF rats to develop more efficacious anticancer immune responses. The different levels of tolerance/regulatory mechanisms in GF versus the CV animals may modulate the anticancer response not only at the mucosal but also at the systemic immunity level.
Spontaneous and Induced Tumors in Germ-Free Animals: A General Review
The role of intestinal microbiota in the pathogenesis of colorectal carcinoma
Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Gnotobiotic mouse model's contribution to understanding host-pathogen interactions
