Complement component c1q and anti-c1q antibodies in theory and in clinical practice
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
18363591
DOI
10.1111/j.1365-3083.2008.02089.x
PII: SJI2089
Knihovny.cz E-resources
- MeSH
- Apoptosis immunology MeSH
- Autoantibodies blood MeSH
- Biomarkers blood MeSH
- Antigen-Antibody Complex immunology MeSH
- Complement Pathway, Classical MeSH
- Complement C1q immunology MeSH
- Humans MeSH
- Lupus Nephritis diagnosis immunology MeSH
- Immunity, Innate MeSH
- Disease Progression MeSH
- Lupus Erythematosus, Systemic blood immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Autoantibodies MeSH
- Biomarkers MeSH
- Antigen-Antibody Complex MeSH
- Complement C1q MeSH
The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.
References provided by Crossref.org
Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women
