Complement component c1q and anti-c1q antibodies in theory and in clinical practice
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
18363591
DOI
10.1111/j.1365-3083.2008.02089.x
PII: SJI2089
Knihovny.cz E-zdroje
- MeSH
- apoptóza imunologie MeSH
- autoprotilátky krev MeSH
- biologické markery krev MeSH
- imunokomplex imunologie MeSH
- klasická dráha komplementu MeSH
- komplement C1q imunologie MeSH
- lidé MeSH
- nefritida při lupus erythematodes diagnóza imunologie MeSH
- přirozená imunita MeSH
- progrese nemoci MeSH
- systémový lupus erythematodes krev imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- autoprotilátky MeSH
- biologické markery MeSH
- imunokomplex MeSH
- komplement C1q MeSH
The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN.
Citace poskytuje Crossref.org
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