Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure
Jazyk angličtina Země Japonsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18840939
DOI
10.2486/indhealth.46.484
PII: JST.JSTAGE/indhealth/46.484
Knihovny.cz E-zdroje
- MeSH
- azbest metabolismus otrava MeSH
- azbestóza metabolismus MeSH
- biologické markery analýza MeSH
- dechové testy metody MeSH
- dinoprost analogy a deriváty analýza metabolismus MeSH
- hodnocení rizik MeSH
- lidé středního věku MeSH
- lidé MeSH
- oxidační stres MeSH
- pracovní expozice MeSH
- prognóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 8-epi-prostaglandin F2alpha MeSH Prohlížeč
- azbest MeSH
- biologické markery MeSH
- dinoprost MeSH
Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
Citace poskytuje Crossref.org
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