Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure
Language English Country Japan Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18840939
DOI
10.2486/indhealth.46.484
PII: JST.JSTAGE/indhealth/46.484
Knihovny.cz E-resources
- MeSH
- Asbestos metabolism poisoning MeSH
- Asbestosis metabolism MeSH
- Biomarkers analysis MeSH
- Breath Tests methods MeSH
- Dinoprost analogs & derivatives analysis metabolism MeSH
- Risk Assessment MeSH
- Middle Aged MeSH
- Humans MeSH
- Oxidative Stress MeSH
- Occupational Exposure MeSH
- Prognosis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 8-epi-prostaglandin F2alpha MeSH Browser
- Asbestos MeSH
- Biomarkers MeSH
- Dinoprost MeSH
Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
References provided by Crossref.org
Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers
Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites
