Cell-protective and antioxidant activity of two groups of synthetic amphiphilic compounds--phenolics and amine N-oxides
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18450220
DOI
10.1007/bf02932187
Knihovny.cz E-zdroje
- MeSH
- aminy chemie farmakologie toxicita MeSH
- antifungální látky toxicita MeSH
- antioxidancia chemie farmakologie toxicita MeSH
- delece genu MeSH
- fenoly chemie farmakologie toxicita MeSH
- kvartérní amoniové sloučeniny chemie farmakologie toxicita MeSH
- membránové lipidy metabolismus MeSH
- mikrobiální viabilita MeSH
- paraquat toxicita MeSH
- peroxidace lipidů MeSH
- Saccharomyces cerevisiae účinky léků MeSH
- superoxiddismutasa genetika MeSH
- terc-butylhydroperoxid toxicita MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- aminy MeSH
- antifungální látky MeSH
- antioxidancia MeSH
- fenoly MeSH
- kvartérní amoniové sloučeniny MeSH
- membránové lipidy MeSH
- paraquat MeSH
- superoxiddismutasa MeSH
- terc-butylhydroperoxid MeSH
Two classes of newly synthesized amphiphilic compounds, phenolic antioxidants ("phenolics") and N-oxides exert in vivo antioxidant effects on live S. cerevisiae cells. Both groups have low toxicity, phenolics being more toxic than N-oxides and compounds with a longer alkyl chain having higher toxicity than those with a shorter alkyl chain. Phenolic antioxidants protect yeast cells exposed to the superoxide producer paraquat and peroxyl generator tert-butylhydroperoxide better than N-oxides at 3-fold higher concentration. Both types of antioxidants enhance the survival of pro-oxidant-exposed cells of S. cerevisiae mutants deficient in cytosolic and/or mitochondrial superoxide dismutase and could be good compounds which mimic the role of superoxide dismutases. The results of measurement of antioxidant activity in an in vitro chemiluminescence test differ from the results obtained in vivo with S. cerevisiae superoxide dismutase mutants. In contrast to their action on live cells, phenolics are less effective than N-oxides in preventing lipid peroxidation of an emulsion of lipids isolated from S. cerevisiae membranes.
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