IgE against food and respiratory allergens in healthy and allergic mothers and their children
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Hypersensitivity MeSH
- Fetal Blood immunology MeSH
- Immunoglobulin E analysis blood MeSH
- Infant MeSH
- Colostrum immunology MeSH
- Humans MeSH
- Maternal-Fetal Exchange MeSH
- Milk, Human immunology MeSH
- Mothers MeSH
- Follow-Up Studies MeSH
- Food Hypersensitivity etiology immunology MeSH
- Respiratory Hypersensitivity etiology immunology MeSH
- Pregnancy MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunoglobulin E MeSH
IgE against mixtures of common food or respiratory allergens were determined by ELISA in healthy (n = 38) and allergic (n = 62) mothers and their children. Significantly higher level of IgE against respiratory allergens was found in sera of allergic mothers and in cord blood of their children. No correlation between antibody level in maternal and newborn's sera was found; this argues against the transfer of IgE from mother to fetus and points rather to offspring's intrauterine sensitization. Specific IgE level in cord blood was higher in children who developed later allergy than in children who did not. Specific IgE level in colostrum was low both in healthy and allergic mothers; there was no correlation between high concentration of IgE against respiratory allergens in sera of allergic mothers and their colostrum, which does not support the idea of IgE transport from blood to mammary gland. Only slightly increased colostral IgE was detected in allergic mothers whose children manifested allergy later. Allergy of the mother and high level of anti-allergen IgE in her serum and in cord blood are the main predictive factors of future occurrence of allergy in the offspring. A combination of several predictive factors could have higher prognostic value.
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