Pathological potential of astroglia
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Grant support
Wellcome Trust - United Kingdom
PubMed
18481910
DOI
10.33549/physiolres.931604
PII: 1604
Knihovny.cz E-resources
- MeSH
- Astrocytes physiology ultrastructure MeSH
- Potassium analysis metabolism MeSH
- Extracellular Space chemistry MeSH
- Gliosis physiopathology MeSH
- Rats MeSH
- Humans MeSH
- Gap Junctions physiology MeSH
- Brain pathology physiology physiopathology MeSH
- Brain Diseases pathology physiopathology MeSH
- Neurons physiology MeSH
- Neurotransmitter Agents metabolism MeSH
- Reactive Oxygen Species metabolism MeSH
- Synapses physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Potassium MeSH
- Neurotransmitter Agents MeSH
- Reactive Oxygen Species MeSH
The pathological potential of glial cells was recognized already by Rudolf Virchow, Santiago Ramon y Cajal and Pio Del Rio-Ortega. Many functions and roles performed by astroglia in the healthy brain determine their involvement in brain diseases; as indeed any kind of brain insult does affect astrocytes, and their performance in pathological conditions, to a very large extent, determines the survival of the brain parenchyma, the degree of damage and neurological defect. Astrocytes being in general responsible for overall brain homeostasis are involved in virtually every form of brain pathology. Here we provide an overview of recent developments in identifying the role and mechanisms of the pathological potential of astroglia.
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