Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
1UC1AI062540-01
NIAID NIH HHS - United States
PubMed
18554916
DOI
10.1016/j.bmc.2008.05.058
PII: S0968-0896(08)00500-2
Knihovny.cz E-zdroje
- MeSH
- antivirové látky chemie MeSH
- cytosin analogy a deriváty chemie MeSH
- guanidiny MeSH
- hydrolýza MeSH
- magnetická rezonanční spektroskopie MeSH
- nukleosidy chemie MeSH
- organofosfonáty chemie MeSH
- stabilita léku MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- 5-azacytosine MeSH Prohlížeč
- antivirové látky MeSH
- cytosin MeSH
- guanidiny MeSH
- nukleosidy MeSH
- organofosfonáty MeSH
Hydrolytic decomposition of four 5-azacytosine acyclic nucleoside phosphonates was studied. Products of the decomposition are carbamoylguanidine derivatives. Stability and decomposition products of HPMP-5-azaC (a 5-azacytosine derivative with strong antiviral activity) differ from the other derivatives. The reaction pathway of HPMP-5-azaC involves a formyl derivative formed by intramolecular transformylation reaction.
Citace poskytuje Crossref.org
Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects
Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity
