A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment
Language English Country England, Great Britain Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
PubMed
18608935
DOI
10.1080/13693780802078180
PII: 793020583
Knihovny.cz E-resources
- MeSH
- Antifungal Agents pharmacology MeSH
- Azoles pharmacology MeSH
- Biofilms * MeSH
- Adult MeSH
- Endocarditis drug therapy microbiology MeSH
- Drug Resistance, Fungal * MeSH
- Humans MeSH
- Mycoses drug therapy microbiology MeSH
- Pichia drug effects isolation & purification pathogenicity physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Azoles MeSH
Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.
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