Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.
- MeSH
- antifungální látky farmakologie MeSH
- azoly farmakologie MeSH
- biofilmy MeSH
- dospělí MeSH
- endokarditida farmakoterapie mikrobiologie MeSH
- financování organizované MeSH
- fungální léková rezistence MeSH
- lidé MeSH
- mykózy farmakoterapie mikrobiologie MeSH
- Pichia fyziologie izolace a purifikace patogenita účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- glukosa fyziologie MeSH
- maláty fyziologie MeSH
- mutace MeSH
- Pichia fyziologie MeSH
- růst MeSH
- Publikační typ
- srovnávací studie MeSH
- MeSH
- enzymová represe MeSH
- fyziologie buňky genetika MeSH
- glukosa fyziologie MeSH
- mutace MeSH
- Pichia fyziologie MeSH
- Publikační typ
- srovnávací studie MeSH
