Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
PubMed
18615283
DOI
10.1080/14756360701811023
PII: 794859466
Knihovny.cz E-zdroje
- MeSH
- acetylcholinesterasa metabolismus MeSH
- aktivace enzymů účinky léků MeSH
- cholinesterasové inhibitory chemie farmakologie MeSH
- fotometrie MeSH
- paraoxon chemie farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- cholinesterasové inhibitory MeSH
- paraoxon MeSH
Photometric microplate assay was performed for testing of paraoxon-inhibited acetylcholinesterase (AChE) using three reactivators for reactivation purposes: obidoxime, pralidoxime, and HI-6. 3-D graphs (percent of reactivation vs. concentration of reactivator and vs. time of reactivator effecting) were constructed for each reactivator to compare their efficacy. The best results were obtained using obidoxime where reactivation was near to 80%. Suitability of photometric microplates for following of reactivation procedures is discussed.
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