Membrane proteins and squalene-hydrosqualene profile in methanoarchaeon Methanothermobacter thermautotrophicus resistant to N,N'-dicyclohexylcarbodiimide
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Drug Resistance, Microbial * MeSH
- Cell Membrane metabolism MeSH
- Dicyclohexylcarbodiimide metabolism pharmacology MeSH
- Energy Metabolism MeSH
- Membrane Proteins genetics metabolism MeSH
- Methanobacteriaceae drug effects genetics metabolism MeSH
- Mutation MeSH
- Squalene chemistry metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dicyclohexylcarbodiimide MeSH
- Membrane Proteins MeSH
- Squalene MeSH
The biochemical basis of a defective bioenergetic system was attempted to be determined in N,N'-dicyclohexylcarbodiimide (DCCD)-resistant mutant of Methanothermobacter thermautotrophicus. Components participating in the maintenance of methanoarchaeal membrane structure and function, such as the composition of the mixture of squalene and its hydrosqualene derivatives and also properties of membrane-associated proteins were compared in wild-type and mutant cells. The impairment of the bioenergetic system in DCCD-resistant mutant was detectable in the membrane-protein profile; it was also accompanied by changes in proportions of squalene-hydrosqualenes.
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