Antibody response of HIV-infected patients to latent, cerebral and recently acquired toxoplasmosis

. 2009 Feb ; 28 (2) : 179-82. [epub] 20080808

Jazyk angličtina Země Německo Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid18688665

The aim of this longitudinal study with 626 HIV-infected patients was to evaluate the capability of serological tests in diagnosing the presence of Toxoplasma gondii infection in HIV-infected patients, as well as the potential impact of various treatment regimes on serological results. Low IgG antibody levels and stable or declining titres predominated. IgM positivity occurred in ten patients (one seroconversion, seven latent, two cerebral toxoplasmosis). Complement fixation test (CFT) titres >or=1:32 imply that the relative risk of cerebral toxoplasmosis is 6.84 (95% confidence interval [CI] 1.44-32.5) but with a predictive value of only 14.0% (95% CI 5.3-27.9). Values of specific antibodies are not biassed by antiretroviral treatment and/or prophylaxis for toxoplasmosis, and the detection of specific antibodies is very useful in the identification of T. gondii infection in the HIV-infected population, but the role of serology in predicting the clinical manifestation of T. gondii infection is limited.

Zobrazit více v PubMed

Clin Microbiol Infect. 2007 Jan;13(1):40-7 PubMed

Infection. 1998 Jan-Feb;26(1):20-5 PubMed

Eur J Clin Microbiol Infect Dis. 1993 Aug;12(8):591-5 PubMed

AIDS. 1991 Nov;5(11):1363-5 PubMed

AIDS. 1996 Nov;10(13):1521-7 PubMed

Clin Infect Dis. 1999 Mar;28(3):575-81 PubMed

Clin Infect Dis. 1992 Aug;15(2):211-22 PubMed

Acta Neurol Scand. 1999 Sep;100(3):178-84 PubMed

J Acquir Immune Defic Syndr (1988). 1993 Apr;6(4):414-8 PubMed

J Eukaryot Microbiol. 2006;53 Suppl 1:S160-1 PubMed

J Clin Microbiol. 2005 Oct;43(10):5044-7 PubMed

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...