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A supercoiled DNA-modified mercury electrode-based biosensor for the detection of DNA strand cleaving agents

. 1998 May ; 46 (1) : 155-61.

Status PubMed-not-MEDLINE Language English Country Netherlands Media print

Document type Journal Article

DNA-damaging agents in the environment represent a serious danger to human health. We use a supercoiled DNA-modified mercury electrode as a fast-response biosensor for the detection of DNA strand cleaving agents. The sensor is based on a strong difference between the a.c. voltammetric responses of covalently closed circular (supercoiled) and of open circular (nicked) plasmid DNA. We show that the sensor can detect hydroxyl radicals in laboratory-prepared solutions and in various natural and industrial water samples. The sensor is also capable of detecting unknown DNA-damaging agents in industrial waters.

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