Surface modification of hydrogels based on poly(2-hydroxyethyl methacrylate) with extracellular matrix proteins
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Extracellular Matrix Proteins chemistry MeSH
- Hydrogels chemistry MeSH
- Hydrogen-Ion Concentration MeSH
- Microscopy, Atomic Force MeSH
- Polyhydroxyethyl Methacrylate analogs & derivatives chemistry MeSH
- Surface Properties MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Extracellular Matrix Proteins MeSH
- Hydrogels MeSH
- polyhydroxyethyl methacrylate hydrogels MeSH Browser
- Polyhydroxyethyl Methacrylate MeSH
Infrared attenuated total reflection spectroscopy was used for in situ observation of the deposition of collagen I on poly(2-hydroxyethyl methacrylate-co-methacrylic acid, 2.9%) hydrogels and subsequent attachment of laminin or fibronectin on the collagen surface. While there was no adsorption of collagen dissolved in an acid solution on the hydrogel surface, it deposited on the surface at pH 6.5. The collagen layers with attached laminin or fibronectin were stable on hydrogel surface in physiological solution. The modification with collagen and particularly with collagen and laminin or fibronectin allowed the adhesion and growth of mesenchymal stromal cells and astrocytes on the hydrogel surface.
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