Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19064320
DOI
10.1016/j.bmcl.2008.11.083
PII: S0960-894X(08)01467-4
Knihovny.cz E-resources
- MeSH
- Esters MeSH
- Isomerism MeSH
- Skin Absorption drug effects MeSH
- Dicarboxylic Acids chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Esters MeSH
- Dicarboxylic Acids MeSH
A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.
References provided by Crossref.org
