Kinetics of dendritic cells reconstitution and costimulatory molecules expression after myeloablative allogeneic haematopoetic stem cell transplantation: implications for the development of acute graft-versus host disease
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19081305
DOI
10.1016/j.clim.2008.10.009
PII: S1521-6616(08)00880-2
Knihovny.cz E-resources
- MeSH
- CD83 Antigen MeSH
- B7-1 Antigen biosynthesis immunology MeSH
- B7-2 Antigen biosynthesis immunology MeSH
- Antigens, CD biosynthesis immunology MeSH
- Dendritic Cells cytology immunology MeSH
- Child MeSH
- Adult MeSH
- Immunophenotyping MeSH
- Immunoglobulins biosynthesis immunology MeSH
- Cohort Studies MeSH
- Humans MeSH
- Membrane Glycoproteins biosynthesis immunology MeSH
- Adolescent MeSH
- Young Adult MeSH
- Graft vs Host Disease immunology pathology MeSH
- Cell Count MeSH
- Child, Preschool MeSH
- Prospective Studies MeSH
- Flow Cytometry MeSH
- Hematopoietic Stem Cell Transplantation methods MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- B7-1 Antigen MeSH
- B7-2 Antigen MeSH
- Antigens, CD MeSH
- CD86 protein, human MeSH Browser
- Immunoglobulins MeSH
- Membrane Glycoproteins MeSH
Allogeneic hematopoetic stem cell transplantation (HSCT) represents a unique opportunity to monitor the kinetics of reconstitution of dendritic cells (DCs) and their dynamics in distinct pathologies. We analyzed DCs reconstitution after myeloablative HSCT. We separately analyzed patients with acute GVHD. DCs were monitored from the earliest phase of hematopoetic reconstitution until day +365. Both myeloid DCs and plasmacytoid DCs appeared at earliest stages after engraftment and relative numbers within white blood cells compartment peaked between days 19-25 after HSCT. Their proportion then gradually declined and absolute numbers of both DC subsets remained lower than in controls during the whole follow-up. Patients with acute GVHD had significantly lower numbers of circulating DCs. Decrease in DC counts preceded onset of clinical symptoms by at least 24 h and was independent of corticosteroids administration. This study reveals quantification of plasmacytoid and myeloid DCs as a potential biomarker for the prediction of acute GVHD development.
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