Compact and low-cost biosensor based on novel approach to spectroscopy of surface plasmons

. 2009 Aug 15 ; 24 (12) : 3430-5. [epub] 20081117

Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic

Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid19109004
Odkazy

PubMed 19109004
DOI 10.1016/j.bios.2008.11.003
PII: S0956-5663(08)00604-0
Knihovny.cz E-zdroje

A high-performance surface plasmon resonance (SPR) sensor based on a novel approach to spectroscopy of surface plasmons is reported. This approach employs a special diffraction grating structure (referred to as surface plasmon resonance coupler and disperser, SPRCD) which simultaneously couples light into a surface plasmon and disperses the diffracted light for spectral readout of SPR signal. The developed SPRCD sensor consists of a miniature cartridge integrating the diffraction grating and microfluidics and a compact optical system which simultaneously acquires data from four independent sensing channels in the cartridge. It is demonstrated that the SPRCD sensor is able to measure bulk refractive index changes as small as 3 x 10(-7) RIU (refractive index units) and to detect short oligonucleotides in concentrations down to 200 pM.

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