Compact and low-cost biosensor based on novel approach to spectroscopy of surface plasmons
Language English Country England, Great Britain Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
19109004
DOI
10.1016/j.bios.2008.11.003
PII: S0956-5663(08)00604-0
Knihovny.cz E-resources
- MeSH
- Equipment Failure Analysis MeSH
- Biosensing Techniques instrumentation MeSH
- Equipment Design MeSH
- Miniaturization MeSH
- Oligonucleotides analysis genetics MeSH
- Surface Plasmon Resonance instrumentation MeSH
- Oligonucleotide Array Sequence Analysis instrumentation MeSH
- Spectrum Analysis instrumentation MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oligonucleotides MeSH
A high-performance surface plasmon resonance (SPR) sensor based on a novel approach to spectroscopy of surface plasmons is reported. This approach employs a special diffraction grating structure (referred to as surface plasmon resonance coupler and disperser, SPRCD) which simultaneously couples light into a surface plasmon and disperses the diffracted light for spectral readout of SPR signal. The developed SPRCD sensor consists of a miniature cartridge integrating the diffraction grating and microfluidics and a compact optical system which simultaneously acquires data from four independent sensing channels in the cartridge. It is demonstrated that the SPRCD sensor is able to measure bulk refractive index changes as small as 3 x 10(-7) RIU (refractive index units) and to detect short oligonucleotides in concentrations down to 200 pM.
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