Adaptor molecules expression in normal lymphopoiesis and in childhood leukemia
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
19183565
DOI
10.1016/j.imlet.2008.12.008
PII: S0165-2478(09)00004-2
Knihovny.cz E-resources
- MeSH
- Adaptor Proteins, Signal Transducing genetics immunology metabolism MeSH
- Adaptor Proteins, Vesicular Transport immunology MeSH
- Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics immunology pathology MeSH
- B-Lymphocytes immunology metabolism pathology MeSH
- Cell Differentiation immunology MeSH
- Cell Lineage MeSH
- Child MeSH
- Humans MeSH
- Lymphopoiesis genetics immunology MeSH
- Membrane Proteins genetics immunology metabolism MeSH
- Biomarkers, Tumor MeSH
- Cell Proliferation MeSH
- Signal Transduction immunology MeSH
- T-Lymphocytes immunology metabolism pathology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Adaptor Proteins, Signal Transducing MeSH
- Adaptor Proteins, Vesicular Transport MeSH
- LAT protein, human MeSH Browser
- LAT2 protein, human MeSH Browser
- LIME1 protein, human MeSH Browser
- Membrane Proteins MeSH
- Biomarkers, Tumor MeSH
- PAG1 protein, human MeSH Browser
Transmembrane adaptor proteins are key mediators of antigen receptor signaling in lymphocytes. By influencing proliferation and differentiation, these molecules might play a role in ethiopathogenesis of acute lymphoblastic leukemia (ALL). The aim of this study was to characterize expression of PAG, LAT, NTAL and LIME adaptors at the mRNA and protein levels in normal B- and T-precursors. Moreover, diagnostic samples of childhood ALL cases were analyzed. During normal lymphocyte development, some adaptors show significant dynamics (gradual decrease of NTAL and increase of LAT and LIME during the T-cell maturation, decrease of PAG in B-precursors, high levels of LIME in peripheral B-lymphocytes). Analysis of childhood ALL samples revealed that in B-cell precursor ALL, the TEL/AML1 subgroup have unique adaptor profile compared to other leukemias. Moreover, NTAL expression separates T lineage leukemias into two subgroups with good and poor response to initial prednisone therapy showing prognostic impact of this molecule in T-ALL.
References provided by Crossref.org
High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells
