In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis
Language English Country Korea (South) Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cyclooxygenase 1 metabolism MeSH
- Cyclooxygenase 2 metabolism MeSH
- Cymenes MeSH
- Dinoprostone biosynthesis MeSH
- Indomethacin pharmacology MeSH
- Cyclooxygenase 2 Inhibitors pharmacology MeSH
- Monoterpenes pharmacology MeSH
- Nitrobenzenes pharmacology MeSH
- Sheep MeSH
- Sulfonamides pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- carvacrol MeSH Browser
- Cyclooxygenase 1 MeSH
- Cyclooxygenase 2 MeSH
- Cymenes MeSH
- Dinoprostone MeSH
- Indomethacin MeSH
- Cyclooxygenase 2 Inhibitors MeSH
- Monoterpenes MeSH
- N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide MeSH Browser
- Nitrobenzenes MeSH
- Sulfonamides MeSH
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E(2) catalysed by COX-2 with an IC(50) value of 0.8 microM what is practically the same concentration as the IC(50) obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 microM and 0.8 microM, respectively. The COX-1 was inhibited approximately at the same rate (IC(50) of 0.7 microM for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
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