In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis
Jazyk angličtina Země Jižní Korea Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- cyklooxygenasa 1 metabolismus MeSH
- cyklooxygenasa 2 metabolismus MeSH
- cymeny MeSH
- dinoproston biosyntéza MeSH
- indomethacin farmakologie MeSH
- inhibitory cyklooxygenasy 2 farmakologie MeSH
- monoterpeny farmakologie MeSH
- nitrobenzeny farmakologie MeSH
- ovce MeSH
- sulfonamidy farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- carvacrol MeSH Prohlížeč
- cyklooxygenasa 1 MeSH
- cyklooxygenasa 2 MeSH
- cymeny MeSH
- dinoproston MeSH
- indomethacin MeSH
- inhibitory cyklooxygenasy 2 MeSH
- monoterpeny MeSH
- N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide MeSH Prohlížeč
- nitrobenzeny MeSH
- sulfonamidy MeSH
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E(2) catalysed by COX-2 with an IC(50) value of 0.8 microM what is practically the same concentration as the IC(50) obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 microM and 0.8 microM, respectively. The COX-1 was inhibited approximately at the same rate (IC(50) of 0.7 microM for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
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