Differential calcium signalling in neuronal-glial networks
Language English Country Singapore Media electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Grant support
Wellcome Trust - United Kingdom
PubMed
19273181
DOI
10.2741/3359
PII: 3359
Knihovny.cz E-resources
- MeSH
- Humans MeSH
- Neuroglia metabolism MeSH
- Neurons metabolism MeSH
- Neurotransmitter Agents metabolism MeSH
- Calcium Signaling * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, N.I.H., Extramural MeSH
- Names of Substances
- Neurotransmitter Agents MeSH
Calcium ions are the probably the most ancient, the most universal and omnipresent intracellular signalling molecules, which are involved in regulation of a host of cellular functional reactions. In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system.
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