Apoferritin applications in nanomedicine
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
25405799
DOI
10.2217/nnm.14.119
Knihovny.cz E-resources
- Keywords
- horse spleen ferritin, magnetic resonance imaging, nanoscale, nanotrasporter, photodynamic therapy, self-assembly, therapeutic agents,
- MeSH
- Apoferritins chemistry therapeutic use MeSH
- Biosensing Techniques MeSH
- Genetic Therapy MeSH
- Protein Conformation MeSH
- Humans MeSH
- Nanomedicine * MeSH
- Drug Carriers MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Apoferritins MeSH
- Drug Carriers MeSH
Nanomedicine as a continuously evolving discipline is still looking for a structure with perfect properties that is usable as a multifunctional transporter. Great potential is attributed to synthetic materials such as fullerenes, porous hollow silica nanoparticles and single-wall nanotubes, among others. However, materials that are natural to the human body are more acceptable by the organism, and thus become an attractive approach in this field of research. Ferritins are proteins that naturally occur in most living organisms throughout evolution and may be a possible transporter choice. Numerous applications have demonstrated the possibilities of iron-free ferritins, called apoferritins, serving as platforms for various nanomedical purposes This article summarizes the advantages and disadvantages of these proteins and discusses their practical applications and future perspectives.
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