Markers of Chlamydia pneumoniae and human cytomegalovirus infection in patients with chronic peripheral vascular disease and their relation to inflammation, endothelial dysfunction and changes in lipid metabolism
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Femoral Artery diagnostic imaging metabolism microbiology pathology virology MeSH
- Popliteal Artery diagnostic imaging metabolism microbiology pathology virology MeSH
- Atherosclerosis diagnostic imaging etiology metabolism microbiology physiopathology virology MeSH
- Leg blood supply MeSH
- Biomarkers MeSH
- Endothelium, Vascular physiopathology MeSH
- Chlamydophila pneumoniae isolation & purification MeSH
- Cytokines blood MeSH
- Cytomegalovirus Infections complications metabolism physiopathology virology MeSH
- DNA, Bacterial analysis blood MeSH
- DNA, Viral analysis blood MeSH
- Adult MeSH
- Dyslipidemias etiology MeSH
- Chlamydophila Infections complications metabolism microbiology physiopathology MeSH
- Ischemia etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipoprotein(a) blood MeSH
- Young Adult MeSH
- Peripheral Vascular Diseases diagnostic imaging etiology metabolism microbiology physiopathology virology MeSH
- Radiography MeSH
- Aged MeSH
- Constriction, Pathologic MeSH
- Vasculitis etiology metabolism microbiology physiopathology virology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Cytokines MeSH
- DNA, Bacterial MeSH
- DNA, Viral MeSH
- Lipoprotein(a) MeSH
Our aim was to detect markers of Chlamydia pneumoniae (CPN) and human cytomegalovirus (HCMV) infection in patients with peripheral vascular occlusive disease and to follow markers of inflammation, endothelial dysfunction and lipid metabolism alteration in patients with active infection. CPN genome was detected in 9 (47.4 %) patients by at least one PCR method. Serological markers of acute CPN infection were found in 5 (26.3 %) subjects; each of them showed also positivity in at least one of the PCR methods. HCMV DNA were detected in 2 (10.5 %) patients; HCMV-specific antibodies were detected in 14 (73.7 %) subjects, however only in IgG subclass. Subjects with HCMV PCR positivity thus showed no serological markers of active HCMV infection. Laboratory findings of acute CPN infection were associated with increased plasma levels of Lp(a), triacylglycerols, atherogenic index of plasma and E-selectin (p < 0.05). No significant differences were found in the other markers, including plasma levels of total cholesterol, ferritin, homocysteine, oxidized LDL, IL-6, IL-8, IL-18, TNF-alpha, soluble forms of VCAM-1 and ICAM-1, von Willebrand factor, C-reactive protein, and plasma nitrites & nitrates. Frequent presence of chlamydial DNA in atheromatous plaques from patients with peripheral vascular disease was confirmed. HCMV DNA was detected only sporadically and with positivity in anamnestic anti-HCMV antibodies (IgG) only, indicating a rare presence of latent virus rather than active replication. Patients with laboratory markers of acute CPN infection exhibited more pronounced alterations in lipid metabolism and endothelial dysfunction.
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