The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Dyskinesias epidemiology MeSH
- Huntington Disease epidemiology MeSH
- Cognition Disorders epidemiology MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Psychomotor Performance MeSH
- Severity of Illness Index MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The relationship between motor symptoms and cognitive impairment in Huntington's disease (HD) is still discussed. We analysed 45 HD patients in various stages using Unified Huntington's Disease Rating Scale motor subscale (voluntary and involuntary components were evaluated separately), verbal memory and executive functions tests. Partial correlations controlling for HD duration and age were used to estimate the relationships among factor scores for motor and cognitive impairment. Voluntary components of motor performance were found to be significantly correlated with verbal short-term memory disturbances (r = -0.361, P = 0.03), with tests of executive functions more dependent on motor performance (r = 0.640, P < 0.01) and also with tests of executive functions less dependent on motor performance (r = 0.461, P < 0.01). Involuntary components did not correlate significantly with any part of cognitive performance.
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Nature. 2000 Feb 3;403(6769):544-9 PubMed
Mov Disord. 1998 Nov;13(6):915-9 PubMed
Brain. 2007 Nov;130(Pt 11):2858-67 PubMed
J Neurol. 1988 Nov;235(8):454-7 PubMed
Mov Disord. 1990;5(2):93-9 PubMed
Neurology. 1989 Jun;39(6):796-801 PubMed
Eur J Neurol. 2007 Dec;14(12):1344-50 PubMed
J Clin Neuropsychol. 1984 Nov;6(4):401-12 PubMed
J Neurosci. 1989 Feb;9(2):582-7 PubMed
J Neurol Neurosurg Psychiatry. 2000 Dec;69(6):773-9 PubMed
Behav Neurosci. 1988 Feb;102(1):141-7 PubMed
Neurology. 1986 Feb;36(2):244-9 PubMed
Brain Res Bull. 2007 Apr 30;72(2-3):152-8 PubMed
Mov Disord. 1999 May;14(3):398-403 PubMed
J Nerv Ment Dis. 1993 Mar;181(3):194-9 PubMed
Neurologist. 2008 Mar;14(2):100-7 PubMed
Mov Disord. 1997 Mar;12(2):229-34 PubMed
J Clin Exp Neuropsychol. 2002 Apr;24(2):133-45 PubMed
Neurol Sci. 2003 Feb;23(6):287-93 PubMed
J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):939-43 PubMed
Neurology. 2005 Sep 13;65(5):745-7 PubMed
Mov Disord. 1996 Mar;11(2):136-42 PubMed
Behav Brain Res. 2008 Feb 11;187(1):153-8 PubMed
Arch Neurol. 1996 Jun;53(6):493-7 PubMed
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):848-52 PubMed
J Neuropsychiatry Clin Neurosci. 2003 Winter;15(1):7-16 PubMed
Neurology. 2002 Mar 12;58(5):695-701 PubMed
Brain. 2008 Apr;131(Pt 4):1057-68 PubMed
Neuropsychologia. 2007 Oct 1;45(13):2922-30 PubMed
Cell. 1993 Mar 26;72(6):971-83 PubMed
J Neurol. 2002 Apr;249(4):437-40 PubMed
J Neuropathol Exp Neurol. 1998 May;57(5):369-84 PubMed
Mov Disord. 2007 Dec;22(16):2297-305; quiz 2452 PubMed
Mov Disord. 2008 Jan 30;23(2):200-6 PubMed
Neurosci Lett. 2007 Apr 18;416(3):272-4 PubMed
Ann Clin Psychiatry. 2008 Jan-Mar;20(1):1-3 PubMed
J Nucl Med. 2001 Nov;42(11):1591-5 PubMed
Ann Neurol. 1986 Dec;20(6):727-31 PubMed
Neurology. 2000 Jan 25;54(2):452-8 PubMed
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