Since the first application of insulin in the 1920s, many clinically necessary changes in the insulin action, effect reduction and extension, hypoglycemia risk reduction and positive weight development have been achieved by way of technological changes of insulin preparations. Such results have been achieved, in particular, by replacing insulin with insulin analogues. The impact on diabetes compensation and on the prevention of complications is not achieved by individual preparations but, in particular, by the quality of treatment and cooperation from the patient. The doctor should know, in particular, the clinical impacts of changes in the structure of insulin preparations as they are indicated in their respective SPCs. The necessary effect extension is achieved by similar technological changes, also with so-called incretin mimetics.

3 interní klinika 1 lékarské fakulty UK a VFN Praha