A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chemical Warfare Agents adverse effects MeSH
- Cholinesterase Inhibitors adverse effects MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Neuroprotective Agents adverse effects therapeutic use MeSH
- Neurotoxicity Syndromes enzymology etiology prevention & control MeSH
- Obidoxime Chloride therapeutic use MeSH
- Organophosphates adverse effects MeSH
- Organophosphorus Compounds adverse effects MeSH
- Oximes therapeutic use MeSH
- Rats, Wistar MeSH
- Cholinesterase Reactivators therapeutic use MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Neuroprotective Agents MeSH
- Obidoxime Chloride MeSH
- Organophosphates MeSH
- Organophosphorus Compounds MeSH
- Oximes MeSH
- Cholinesterase Reactivators MeSH
- tabun MeSH Browser
The neuroprotective effects of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with tabun at a sublethal dose (180 microg/kg i.m.; 80% LD(50)) were studied. The tabun-induced neurotoxicity was monitored by using a functional observational battery and an automatic measurement of motor activity. The neurotoxicity of tabun was monitored at 24 hours and 7 days following tabun challenge. The results indicate that K203 and obidoxime in combination with atropine allow all tabun-poisoned rats to survive within 7 days following tabun challenge, while 2 nontreated tabun-poisoned rats and 1 tabun-poisoned rat treated with K206 or HI-6 in combination with atropine died within 7 days. Only one of the newly developed oximes (K203) combined with atropine seems to be effective for a decrease in tabun-induced neurotoxicity within 24 hours after tabun sublethal poisoning, although it is not able to eliminate tabun-induced neurotoxicity completely. On the other hand, the neuroprotective efficacy of commonly used oximes (obidoxime and HI-6), as well as one of the new synthesized oximes (K206), is significantly lower in comparison with K203, according to the number of eliminated tabun-induced neurotoxic signs at 24 hours after tabun challenge. Due to its neuroprotective effects, K203 appears to be a suitable oxime for the antidotal treatment of acute tabun poisonings.
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