Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19539780
DOI
10.1016/j.vph.2009.06.001
PII: S1537-1891(09)00072-X
Knihovny.cz E-resources
- MeSH
- Acetophenones pharmacology MeSH
- Analysis of Variance MeSH
- Angiotensin II analysis blood physiology urine MeSH
- Antioxidants pharmacology MeSH
- Time Factors MeSH
- Cyclic N-Oxides pharmacology MeSH
- Dinoprost analogs & derivatives urine MeSH
- Hypertension complications physiopathology prevention & control MeSH
- Cardiomegaly complications prevention & control MeSH
- Blood Pressure MeSH
- Rats MeSH
- Kidney chemistry MeSH
- Malondialdehyde analysis MeSH
- Disease Models, Animal MeSH
- Myocardium chemistry MeSH
- Random Allocation MeSH
- Kidney Diseases complications prevention & control MeSH
- Oxidative Stress physiology MeSH
- Rats, Sprague-Dawley MeSH
- Rats, Transgenic MeSH
- Proteinuria MeSH
- Renin genetics MeSH
- Free Radical Scavengers pharmacology MeSH
- Spin Labels MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 8-epi-prostaglandin F2alpha MeSH Browser
- Acetophenones MeSH
- acetovanillone MeSH Browser
- Angiotensin II MeSH
- Antioxidants MeSH
- Cyclic N-Oxides MeSH
- Dinoprost MeSH
- Malondialdehyde MeSH
- Ren2 protein, rat MeSH Browser
- Renin MeSH
- Free Radical Scavengers MeSH
- Spin Labels MeSH
- tempol MeSH Browser
Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apocynin on the development of hypertension. Systolic blood pressure (SBP) was monitored from 30 to 99 days of age in TGR and in normotensive Hannover Sprague-Dawley (HanSD) rats. At the end of the experiment, urinary protein and 8-isoprostane excretion were determined and angiotensin II (ANG II) and malondialdehyde (MDA) levels were measured in kidney and cardiac tissues. Cardiac hypertrophy was assessed as the ratio of left heart ventricle weight to tibia length (LVW/TL). Although tempol and apocynin treatment in TGR significantly decreased 8-isoprostane excretion and MAD tissue concentrations as compared with untreated TGR, it did not alter the course of SBP, LVW/TL ratio, proteinuria or ANG II levels that were enhanced as compared with HanSD rats. Our data suggest that the development of hypertension in TGR is clearly ANG II-dependent but the contribution of oxidative stress to the development of hypertension in this model appears to be negligible.
References provided by Crossref.org
Sex differences in blood pressure of aged Ren-2 transgenic rats
