May alcohol-induced increase of HDL be considered as atheroprotective?
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
19681657
DOI
10.33549/physiolres.931769
PII: 931769
Knihovny.cz E-resources
- MeSH
- Apolipoprotein A-I blood MeSH
- Atherosclerosis blood prevention & control MeSH
- Biomarkers blood MeSH
- Biological Transport MeSH
- Adult MeSH
- Cholesterol, HDL blood MeSH
- Cross-Over Studies MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Macrophages metabolism MeSH
- Alcohol Drinking blood MeSH
- Beer * MeSH
- Up-Regulation MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- APOA1 protein, human MeSH Browser
- Apolipoprotein A-I MeSH
- Biomarkers MeSH
- Cholesterol, HDL MeSH
It is well known that the consumption of moderate doses of alcohol leads to the increase of HDL-cholesterol (HDL-C). Atheroprotectivity of HDL particles is based primarily on their role in reverse cholesterol transport (RCT). In the study with a cross-over design 13 male volunteers were studied in two different regimens: i) drinking of 36 g alcohol daily and ii) drinking only non-alcoholic beverages, to test whether alcohol-induced increase of HDL cholesterol can affect cholesterol efflux (CHE) from cell culture of labeled human macrophages. Alcohol consumption induced significant (p < 0.05) increases of HDL cholesterol from 1.25 +/- 0.32 to 1.34 +/- 0.38 mmol/l and Apo A1 from 1.34 +/- 0.16 to 1.44 +/- 0.19 g/l. These changes were combined with a slight increase of cholesterol efflux from 13.8 +/- 2.15 to 14.9 +/- 1.85 % (p = 0.059). There were significant correlations between individual changes of HDL-C and Apo A1 concentrations and individual changes of CHE (0.51 and 0.60, respectively). In conclusion, moderate alcohol consumption changes the capacity of plasma to induce CHE only at a border line significance.
References provided by Crossref.org
Cholesterol efflux and macrophage polarization in human adipose tissue