Dva typy cytomegalovirového postizení oka u pacientů s HIV infekcí
[Two types of CMV ocular complications in patients with HIV infection]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Review
PubMed
19916157
- MeSH
- Cytomegalovirus Retinitis complications MeSH
- Cytomegalovirus Infections complications MeSH
- HIV Infections complications drug therapy MeSH
- Immune Reconstitution Inflammatory Syndrome complications MeSH
- Humans MeSH
- AIDS-Related Opportunistic Infections * MeSH
- Uveitis complications virology MeSH
- Check Tag
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Review MeSH
CMV retinitis is the most serious ocular complication of AIDS. Introduction of the combination antiretroviral therapy markedly reduced the occurrence of CMV retinitis, on the other hand it brought a new ocular complication - CMV uveitis. CMV uveitis is an immunopathological inflammatory reaction associated with the immune reconstitution inflammatory syndrome, which is a side effect of successfully initiated cART. These two forms of CMV ocular complications differ in pathogenesis, symptomatology and therapy. The CMV retinitis is treated with anti-CMV virostatics whereas the therapy of CMV uveitis is based on attenuation of the inflammatory reaction by administration of corticosteroids. The optimal prevention of both complications is an early initiation of cART before the CD4+ T lymphocytes drop below 200/microl.
