Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs
Language English Country United States Media print-electronic
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anti-Inflammatory Agents, Non-Steroidal * MeSH
- Duodenum pathology MeSH
- Duodenal Ulcer chemically induced diagnosis MeSH
- Ileum pathology MeSH
- Indomethacin * MeSH
- Jejunum pathology MeSH
- Capsule Endoscopy * MeSH
- Peptic Ulcer Hemorrhage chemically induced diagnosis MeSH
- Disease Models, Animal MeSH
- Intestinal Diseases chemically induced diagnosis MeSH
- Predictive Value of Tests MeSH
- Sensitivity and Specificity MeSH
- Intestinal Mucosa pathology MeSH
- Sus scrofa MeSH
- Intestine, Small pathology MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Inflammatory Agents, Non-Steroidal * MeSH
- Indomethacin * MeSH
AIM: The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs. MATERIALS AND METHODS: Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3+/-2.4 kg. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (Olympus Optical Co., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed. RESULTS: Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively. CONCLUSION: Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.
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