Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu hodnotící studie, časopisecké články, práce podpořená grantem
- MeSH
- antiflogistika nesteroidní * MeSH
- duodenum patologie MeSH
- dvanáctníkové vředy chemicky indukované diagnóza MeSH
- ileum patologie MeSH
- indomethacin * MeSH
- jejunum patologie MeSH
- kapslová endoskopie * MeSH
- krvácení z peptického vředu chemicky indukované diagnóza MeSH
- modely nemocí na zvířatech MeSH
- nemoci střev chemicky indukované diagnóza MeSH
- prediktivní hodnota testů MeSH
- senzitivita a specificita MeSH
- střevní sliznice patologie MeSH
- Sus scrofa MeSH
- tenké střevo patologie MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antiflogistika nesteroidní * MeSH
- indomethacin * MeSH
AIM: The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs. MATERIALS AND METHODS: Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3+/-2.4 kg. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (Olympus Optical Co., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed. RESULTS: Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively. CONCLUSION: Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.
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