Antioxidant and antiviral activities of silybin fatty acid conjugates
Language English Country France Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20036447
DOI
10.1016/j.ejmech.2009.11.056
PII: S0223-5234(09)00626-6
Knihovny.cz E-resources
- MeSH
- Acylation MeSH
- Antioxidants pharmacology MeSH
- Antiviral Agents pharmacology MeSH
- Cell Line MeSH
- Esterification MeSH
- Magnetic Resonance Spectroscopy MeSH
- Fatty Acids pharmacology MeSH
- Molecular Structure MeSH
- Orthomyxoviridae drug effects MeSH
- Dogs MeSH
- Silybin MeSH
- Silymarin pharmacology MeSH
- Cell Survival drug effects MeSH
- Animals MeSH
- Check Tag
- Dogs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antioxidants MeSH
- Antiviral Agents MeSH
- Fatty Acids MeSH
- Silybin MeSH
- Silymarin MeSH
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.
References provided by Crossref.org
Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues
Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers
